AP CELL CYCLE CONTROL

When you click Submit (at the bottom of this web page) it will save your work on the server for me. If you get a "proxy error" hit -refresh- until you get a "Thanks"

You might want to actually write your answers in Word (so you can spell check them) and then cut-and-paste into the boxes. That way, if the computer misplaces your work you can just re-paste the answers.

Since you may work on this over more than one day, and you can work at home, I will keep track of what you have done. Feel free to click submit as you work to save your work to the server.

TAB OR USE THE MOUSE Between the fields....

Answer the questions as best you can. The boxes will expand as you type if you need more space. (Don't worry if it is a one word answer. The box size is standard.)

Since you will be working in groups, put all the names of the people in the group in the box. The ideal group size is 2. As an exception I will allow groups of 3. No groups of 4 or 5. If you work as a group of 3 I expect better answers. Group sizes above 3 will be penalized in the grading.

Name(s):

Class Period

.In 2001 3 men won the Nobel Prize in Physiology based on their work on the regulation of the cell cycle. Go to the page linked below and follow the link in the right hand column that says "Illustrated Presentation."

Nobel Prize 2001

Go through the explanations and the game, answering my questions.

Question 1: Why do you think all three men work at research centers where the study of cancer is the focus?

Question 2: In the "Introduction" the text says "CDK and cyclin drive the cell..." What is meant by the term "drive" in this context?

Question 3: What controls the transition from G2 to M?

Question 4: When (in the section on Paul Nurse) it says "...the CDK fuction has been conserved through evolution." what does it mean?

Question 5: Which part of the kinase complex is constant throughout the cell cycle? Which part varies in concentration?

Remember, the boxes will expand as you type if you need more space.

Question 6: What happens to the level of cyclins during mitosis?

Play the "Control of the Cell Cycle Game" (you can use the link here or at the bottom of the Nobel site's web pages).

Question 7: While the game loads you can click on the cells and they do something. How many pairs of chromosomes does this simulated cell have?

Question 8: In the "game" what does the first checkpoint check for?

Question 9: In the game what does the second checkpoint check for?

Question 10: What does the third checkpoint check for?